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Dionamix NanoStation

Precise
High Throughput
Innovative

All-In-One Automated Solution LNP Synthesis

Inspiring Broader Research

Dionamix Scientific's new breakthrough in lipid nanoparticle medicine research eliminates potential human error and improves accuracy and precision to aid in nucleic acid-based and small molecule medicine development.

Evolution of LNP Production

Lipidnanoparticle Production Systems and Processes Evolution

Traditional Lipid Nanoparticle Production Methods & Instruments

Existing Lipid Nanoparticle Production Machines

Dionamix Scientific Inc. NanoStation

Formulation

Mix Preparation

Mixing

Scale-up

  • Manually calculate dilution, mole weight ratio and flow rate ratio

  • Typically single formulation per experiment run

  • Manually calculate dilution, mole weight ratio and flow rate ratio

  • Typically single formulation per experiment run

  • Data entry and automated calculation

  • Integrated formulation verification

  • Records retention

  • Multiple formulations per experiment run

  • Manually prepare aqueous/payload and organic/carrier stock solutions

  • Manually dilute solutions according to formulation

  • Human errors lead to potential inconsistencies

  • Manually prepare aqueous/payload and organic/carrier stock solutions

  • Manually dilute solutions according to formulation

  • Human errors lead to potential inconsistencies

  • Manually prepare aqueous/payload and organic/carrier stock solutions

  • Automatically dilute solutions for various formulations

  • Automated machine processing reduces inconsistencies and errors

  • Set up for single use individual formulation

  • Manually asperate syringes with formulation volumes

  • Manually set up mechanical syringe pump parameters for LNP mixing

  • Set up for single use individual formulation

  • Manually asperate syringes with formulation volumes

  • Mixing parameter set up in syringe pump interface

  • One-time use proprietary microfluidic chips

  • Single sample formulation process

  • Designed for high throughput multi-formulations

  • Completely automated asperation and mixing process

  • Integrated set up and execution of formulation experiments

  • High throughput continuous sample formulation process

  • Typically limited to research only

  • Dedicated instrument typically designed for each stages

  • Single system for high throughput research, in vitro, or in vivo scaled-up testing

NanoStation: Single flexible solution from research to scale-up

NanoStation Automated Lipid Nanoparticle Assembly Process

NanoStation Automated Lipidnanoparticle Assembly Process

1. Derive Formulations

6. Scale-up

5. Collect & Process Samples

2. Calculate Formulation Parameters

3. Prepare Aqueous & Organic Solutions

4. Synthesize Nanoparticles

Key Advantages

Research Data Management

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The system will automatically capture experimental parameters, measurements and any observations to reduce human error and overall enhance data accuracy. Researchers can securely store and access their data at any time.

Accurate Results

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The automated system will eliminate the chances of human error and inaccuracies in the experiment. With the increasing volume of data generated, the system will provide scalable data storage and management solutions

Rapid Formulation Throughput

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The automation of the formulation processes will accelerate throughput. This includes the automation of preparation, mixing and target validation.

Innovative

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By eliminating manual intervention, researchers and scientists can save significant time and reduce common human errors, resulting in increased productivity and improved results.

1

Genomic

Medicines

Dionamix's new breakthrough will revolutionize lipid nanoparticle research and accelerate the development of genomic medicines. By accelerating the research phase, new therapies and development of genomic medicines will improve patient outcomes and the medicinal industry.

2

Small Molecule Medicines

Small molecule medicines can play an integral role in treating various diseases, including Lipid Nanoparticle (LNP) - based delivery systems. LNPs often used to encapsulate and deliver these small molecules to specific targets in the body. 

3

Nucleic Acid 

Medicines

Nucleic acid drugs are currently being developed as novel therapeutic modalities. It is being studied to treat human diseases like cancers, genetic disorders and viral infections in the body. With our new breakthrough, researchers will be able to accelerate the long and repetitive research phase to new discoveries. 

Applications

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